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  2. 5-Hydroxyindoleacetic acid - Wikipedia

    en.wikipedia.org/wiki/5-Hydroxyindoleacetic_acid

    5-Hydroxyindoleacetic acid (5-HIAA) is the main metabolite of serotonin. The metabolic intermediate 5-hydroxyindoleacetaldehyde (5-HIAL) is formed from serotonin by monoamine oxidase (MAO) and then 5-HIAA is formed from 5-HIAL via aldehyde dehydrogenase (ALDH). In chemical analysis of urine samples, 5-HIAA is used to determine serotonin levels ...

  3. Serotonin - Wikipedia

    en.wikipedia.org/wiki/Serotonin

    Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.

  4. Central nervous system fatigue - Wikipedia

    en.wikipedia.org/wiki/Central_Nervous_System_Fatigue

    In the brain, serotonin is a neurotransmitter and regulates arousal, behavior, sleep, and mood, among other things. [9] During prolonged exercise where central nervous system fatigue is present, serotonin levels in the brain are higher than normal physiological conditions; these higher levels can increase perceptions of effort and peripheral muscle fatigue. [9]

  5. Escitalopram (Lexapro): Everything You Need to Know Before ...

    www.aol.com/escitalopram-lexapro-everything-know...

    Serotonin syndrome is a potentially life-threatening drug reaction that causes the body to have too much serotonin. It can be caused by certain drug interactions, as well as drinking alcohol while ...

  6. No ‘clear evidence’ depression is caused by low serotonin levels

    www.aol.com/no-clear-evidence-depression-caused...

    NHS figures show that the number of people in England taking antidepressants continues to rise, with 8.3m patients receiving them in 2021/22.

  7. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    Serotonin may indirectly influence mood by altering emotional processing biases that are seen at both the cognitive/behavioral and neural level. [43] [42] Pharmacologically reducing serotonin synthesis, and pharmacologically enhancing synaptic serotonin can produce and attenuate negative affective biases, respectively. These emotional ...

  8. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...

  9. Acute tryptophan depletion - Wikipedia

    en.wikipedia.org/wiki/Acute_tryptophan_depletion

    This experimental approach reduces the availability of tryptophan, an amino acid which serves as the precursor to serotonin. [ 1 ] [ 2 ] The lack of mood-lowering effects after ATD in healthy subjects seems to contradict a direct causal relationship between acutely decreased serotonin levels and depression.

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