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Activation of a wide range of serotonin receptors by serotonin itself or by certain prokinetic drugs results in enhanced gastrointestinal motility. [3] Other prokinetic drugs may increase acetylcholine concentrations by stimulating the M 1 receptor which causes acetylcholine release, or by inhibiting the enzyme acetylcholinesterase which ...
Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT 4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system.
Mosapride is a gastroprokinetic agent that acts as a selective 5HT 4 agonist.The major active metabolite of mosapride, known as M1, additionally acts as a 5HT 3 antagonist, [1] which accelerates emptying throughout the whole of the gastrointestinal tract in humans, [2] and is used for the treatment of gastritis, gastroesophageal reflux disease, functional dyspepsia [3] and irritable bowel ...
Generally, drugs outlined within the ATC code A should be included in this category. Please see WP:PHARM:CAT for more information. Wikimedia Commons has media related to Gastrointestinal system drugs .
These drugs inhibit dopamine and acetylcholine esterase enzyme and have a gastrokinetic effect. [3] Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. [4] It is a combined D 2 receptor antagonist and acetylcholinesterase inhibitor. [5] [6] Itopride is the dimethoxy analog of trimethobenzamide.
[25] [26] [2] However, it is available in the United States for people with severe and treatment-refractory gastrointestinal motility problems under an expanded access individual-patient investigational new drug application. [25] An analogue of domperidone called deudomperidone is under development for potential use in the United States and ...
Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating diarrhea symptoms and improving stool consistency and frequency. [4] Unlike other opiates, loperamide does not cross the blood brain barrier, so there is minimal risk for abuse. [5]
Lubiprostone is a bicyclic fatty acid [15] derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements.