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The physical background of the mixing rule is the fact that the heat energy of a substance is directly proportional to its mass and its absolute temperature. The proportionality factor is the specific heat capacity, which depends on the nature of the substance, but which was not described until some time after Richmann's discovery by Joseph Black.
The Alias flip is a very powerful mix between an Elias flip and an Ali flip. The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E. Alcohol: Benzodiazepine: Time flip Time flipping Alcohol: Caffeine: Caffeinated alcoholic drink: Alcohol: Cannabis: Tincture of cannabis. Herb and Al ...
Donna Levin’s novel Extraordinary Means is a literary fantasy in which a young woman, although diagnosed in an irreversible coma, also brought on by an accidental combination of drugs and alcohol, is able to observe her family members debate over whether or not to withdraw life support.
Dealers are mixing it with other illicit drugs and selling it. Just 2 milligrams of fentanyl is considered a lethal dose, according to the DEA. Dealers are mixing it with other illicit drugs and ...
Pharmacotherapy, also known as pharmacological therapy or drug therapy, is defined as medical treatment that utilizes one or more pharmaceutical drugs to improve ongoing symptoms (symptomatic relief), treat the underlying condition, or act as a prevention for other diseases (prophylaxis).
Alcohol is also converted into phosphatidylethanol (PEth, an unnatural lipid metabolite) by phospholipase D2. This metabolite competes with PIP 2 agonist sites on lipid-gated ion channels. [28] [29] The result of these direct effects is a wave of further indirect effects involving a variety of other neurotransmitter and neuropeptide systems. [25]
Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death .
Combination therapy or polytherapy is therapy that uses more than one medication or modality. Typically, the term refers to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression).