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Intercalated discs are complex structures that connect adjacent cardiac muscle cells. The three types of cell junction recognised as making up an intercalated disc are desmosomes, fascia adherens junctions, and gap junctions. [2] Fascia adherens are anchoring sites for actin, and connect to the closest sarcomere. [3]
Intercalated discs are part of the cardiac muscle cell sarcolemma and they contain gap junctions and desmosomes. The cardiac syncytium is a network of cardiomyocytes connected by intercalated discs that enable the rapid transmission of electrical impulses through the network, enabling the syncytium to act in a coordinated contraction of the ...
All cardiac muscle cells are electrically linked to one another, by intercalated discs which allow the action potential to pass from one cell to the next. [1][2] This means that all atrial cells can contract together, and then all ventricular cells. Different shapes of the cardiac action potential in various parts of the heart.
Details of intercalated discs. Cardiomyocytes, are considerably shorter and have smaller diameters than skeletal myocytes. Cardiac muscle (like skeletal muscle) is characterized by striations – the stripes of dark and light bands resulting from the organised arrangement of myofilaments and myofibrils in the sarcomere along the length of the cell.
In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy.
However, cardiac muscle cells contain a diad, which is a linking of only one sarcoplasmic reticulum with its respective t-tubule. Another notable distinction between all muscle cells and cardiac muscle cells is the presence of intercalated discs. These tight connections between the cardiomyocytes allows for the accelerated sending of action ...
Fascia adherens. In anatomy for cardiac muscle, fascia adherens are ribbon-like structures that stabilize non-epithelial tissue. They are similar in function and structure to the zonula adherens or adherens junction of epithelial cells. It is a broad intercellular junction in the transversal sections of an intercalated disc of cardiac muscle ...
Cardiac muscle cells form the cardiac muscle in the walls of the heart chambers, and have a single central nucleus. [7] Cardiac muscle cells are joined to neighboring cells by intercalated discs, and when joined in a visible unit they are described as a cardiac muscle fiber. [8] Smooth muscle cells control involuntary movements such as the ...