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Alzheimer’s drug Leqembi, the first medicine shown to slow the disease, has earned FDA approval. Learn more about the treatment and what this means for patients.
Aducanumab is a monoclonal IgG1 antibody that binds to the amyloid beta protein at amino acids 3–7, which is posited to result in slowing the progression of Alzheimer's disease. [ 5 ] The mechanism is based on the amyloid hypothesis, which posits that amyloid proteins cause Alzheimer's disease, hence removing amyloid should slow the ...
The US Food and Drug Administration (FDA) label for donanemab contains a boxed warning about amyloid-related imaging abnormalities. [1]Side effects may include infusion-related reactions, with symptoms such as flu-like symptoms, nausea, vomiting and changes in blood pressure, and hypersensitivity reactions, including anaphylaxis (severe, life-threatening allergic reaction) and angioedema ...
Westend61/Getty Images. A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide ...
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2 ] and is the cause of 60–70% of cases of dementia. [ 2 ][ 15 ] The most common early symptom is difficulty in remembering recent events. [ 1 ] As the disease advances, symptoms can include problems with language, disorientation ...
The FDA had proposed that companies testing new anti-amyloid drugs exclude any volunteer from clinical trials who had more than two brain microbleeds, according to an Alzheimer's Assn. report.
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