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Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purines and their tautomers. They are the most widely occurring nitrogen-containing heterocycles in nature. [1]
Purine metabolism can have imbalances that can arise from harmful nucleotide triphosphates incorporating into DNA and RNA which further lead to genetic disturbances and mutations, and as a result, give rise to several types of diseases. Some of the diseases are: Severe immunodeficiency by loss of adenosine deaminase.
Haig's diet was thus to restrict foods high in purines. In 1911, Haig claimed that he lived on a uric-acid free diet and that his turnover of uric acid was under 10gr which is far under a meat-eaters diet which is over 20gr. [14] Purines are present in meat foods and high consumption of these foods has been implicated in causing gout, bladder ...
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [ 1 ]
1–2% (developed world) [ 7 ] Gout (/ ɡaʊt / GOWT[ 9 ]) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and swollen joint, [ 4 ][ 10 ] caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals. [ 11 ]
Nucleotide salvage. A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. The term often refers to nucleotide salvage in particular, in which nucleotides (purine and pyrimidine) are synthesized from intermediates in their degradative pathway.
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