Search results
Results from the WOW.Com Content Network
Asparagine (symbol Asn or N [2]) is an α-amino acid that is used in the biosynthesis of proteins.It contains an α-amino group (which is in the protonated −NH + 3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO − form under biological conditions), and a side chain carboxamide, classifying it as a polar (at physiological pH), aliphatic ...
Asparagine endopeptidase (AEP, mammalian legumain, δ-secretase; EC 3.4.22.34) is a proteolytic enzyme from C13 peptidase family which hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile (hence also called cysteine protease).
3-Hydroxyasparagine also known as β-hydroxyasparagine (beta-hydroxyasparagine) is a modified asparagine amino acid. It appears in posttranslational modification of cbEGF-like domains which can occur in humans and other Eukaryotes. The amino acid code used for this is Hyn. The modified amino acid residue is found in fibrillin-1. [1]
This depletion of serum asparagine leads to a subsequent rapid efflux of cellular asparagine, which is immediately acted upon and destroyed by the L-asparaginase as well. [5] Due to the transient response from these susceptible cancers in reaction to the asparagine depletion, tumor growth is significantly inhibited due to nutritional deficiency.
Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...
Potassium asparaginate is a potassium salt of L-asparagine amino acid. [2] [3] [4] [5]Potassium asparaginate can be considered both a salt and a coordination complex. [6] [3] As a salt, potassium asparaginate is formed when the potassium ion (K +) replaces the hydrogen ion (H +) in the carboxyl group of L-asparagine, an amino acid; in this process, the carboxyl group (–COOH) in L-asparagine ...
Insulin glulisine, sold under the brand name Apidra among others, is a rapid-acting modified form of medical insulin used for the treatment of diabetes.It differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. [2]
66514 Ensembl ENSG00000162174 ENSMUSG00000024654 UniProt Q7L266 Q8C0M9 RefSeq (mRNA) NM_001083926 NM_025080 NM_025610 RefSeq (protein) NP_001077395 NP_079356 NP_079886 Location (UCSC) Chr 11: 62.34 – 62.39 Mb Chr 19: 9.09 – 9.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene. Function The ASRGL1 protein ...