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However, not all of them are safe to use during pregnancy. One of the components of bismuth subsalicylate is salicylate, which is a component that crosses the placenta. Due to this, there is an increased risk for intrauterine growth retardation, fetal hemorrhage, and maternal hemorrhage within organogenesis and in the second/third trimester. [ 12 ]
Common side effects for oral decongestants include insomnia, hypertension (elevated blood pressure), and difficulty in urination. [12] Avoid use during pregnancy as it may cause vasoconstriction of uterine arteries thus reducing fetal blood supply. [14] Zyrtec-D, an example of combination therapy. Combination therapy with antihistamines
[4] [5] Use is not recommended during pregnancy. [2] Xylometazoline is in the decongestant and alpha-adrenergic agonist families of medication. [5] [6] One study classified it with selectivity ratios in alpha 2 adrenergic receptors of 151 for a2A vs a2B, 4.5 a2A vs a2C, and 33.9 a2B vs a2C. Making it a highly selective a2A agonist. [7]
It is unclear if use is safe during pregnancy or breastfeeding. [9] It is a second-generation antihistamine and works by blocking the release of a number of inflammatory mediators including histamine. [7] [8] Azelastine was patented in 1971 and came into medical use in 1986. [10] It is available as a generic medication.
Pseudoephedrine is the most common oral decongestant alternative, but since it has potential for abuse, you’ll likely need to ask a pharmacist for help accessing it behind the counter.
Use during pregnancy appears to be safe but has not been well studied. [7] It is not recommended in children less than two years old. [6] It is in the second-generation antihistamine family of medication. [5] Loratadine was patented in 1980 and came to market in 1988. [8] It is on the World Health Organization's List of Essential Medicines. [9]
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