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The carboxypeptidase A family can be divided into two subfamilies: carboxypeptidase H (regulatory) and carboxypeptidase A (digestive). [1] Members of the H family have longer C-termini than those of family A, [2] and carboxypeptidase M (a member of the H family) is bound to the membrane by a glycosylphosphatidylinositol anchor, unlike the majority of the M14 family, which are soluble.
Carboxypeptidase A (CPA) contains a zinc (Zn 2+) metal center in a tetrahedral geometry with amino acid residues in close proximity around zinc to facilitate catalysis and binding. Out of the 307 amino acids bonded in a peptide chain, the following amino acid residues are important for catalysis and binding; Glu-270, Arg-71, Arg-127, Asn-144 ...
A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases , which cleave peptide bonds at the N-terminus of proteins.
1969 – Carboxypeptidase A is a zinc metalloprotease. Its crystal structure (PDB file 1CPA) [21] showed the first parallel beta structure: a large, twisted, central sheet of 8 strands with the active-site Zn located at the C-terminal end of the middle strands and the sheet flanked on both sides with alpha helices.
Zinc fingers help read DNA sequences.. Zinc is an essential trace element for humans [1] [2] [3] and other animals, [4] for plants [5] and for microorganisms. [6] Zinc is required for the function of over 300 enzymes and 1000 transcription factors, [3] and is stored and transferred in metallothioneins.
Zinc carboxypeptidase This page was last edited on 13 March 2019, at 11:15 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 License ...
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71791 Ensembl n/a ENSMUSG00000039070 UniProt Q9UI42 Q6P8K8 RefSeq (mRNA) NM_016352 NM_001163446 NM_027926 RefSeq (protein) NP_001156918 NP_057436 NP_082202 Location (UCSC) n/a Chr 6: 30.57 – 30.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene. This gene is a member of the carboxypeptidase A/B subfamily ...