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Lipids are a broad group of organic compounds which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes.
Since lipids are hydrophobic molecules, they need to be solubilized before their metabolism can begin. Lipid metabolism often begins with hydrolysis, [7] which occurs with the help of various enzymes in the digestive system. [2] Lipid metabolism also occurs in plants, though the processes differ in some ways when compared to animals. [8]
The IUPAC Lipid Handbook provides a very large and detailed listing of fat contents of animal and vegetable fats, including ω−3 and −6 oils. [25] The National Institutes of Health's EFA Education group publishes Essential Fats in Food Oils. [26] This lists 40 common oils, more tightly focused on EFAs and sorted by n−6:3 ratio.
The surface of a curved lipid bilayer. Lipidology is the scientific study of lipids. Lipids are a group of biological macromolecules that have a multitude of functions in the body. [1] [2] [3] Clinical studies on lipid metabolism in the body have led to developments in therapeutic lipidology for disorders such as cardiovascular disease. [4]
Lipids provide animals with fats and oils. They are not soluble in water, and they can store energy for an extended period of time. They can be obtained from many different plant and animal sources. Most dietary lipids are triglycerides, composed of glycerol and fatty acids. Phospholipids and sterols are found in smaller amounts. [30]
The pyruvate produced by glycolysis is an important intermediary in the conversion of carbohydrates into fatty acids and cholesterol. [34] This occurs via the conversion of pyruvate into acetyl-CoA in the mitochondrion. However, this acetyl-CoA needs to be transported into cytosol where the synthesis of fatty acids and cholesterol occurs.
The lipids carried include cholesterol, phospholipids, and triglycerides, amounts of each are variable. [ 3 ] Increasing concentrations of HDL particles are associated with decreasing accumulation of atherosclerosis within the walls of arteries, [ 4 ] reducing the risk of sudden plaque ruptures , cardiovascular disease , stroke and other ...
As a rule of thumb, the epidermal lipid matrix is composed of an equimolar mixture of ceramides (≈50% by weight), cholesterol (≈25% by weight), and free fatty acids (≈15% by weight), with smaller quantities of other lipids also being present. [34] [35] Cholesterol sulfate reaches its highest concentration in the granular layer of the ...
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