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Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia. [11] It is a long-acting [12] tranquilizer of the benzodiazepine class. [11]
When symptoms increase periodically during protracted withdrawal, physiological changes may be present, including dilated pupils as well as an increase in blood pressure and heart rate. [9] The change in symptoms has been proposed to be due to changes in receptor sensitivity for GABA during the process of tolerance reversal. [ 25 ]
Benzodiazepine dependence develops with long-term use, even at low therapeutic doses, [2] often without the described drug seeking behavior and tolerance. [ 3 ] [ 4 ] Addiction consists of people misusing or craving the drug, not to relieve withdrawal symptoms, but to experience its euphoric or intoxicating effects.
For example, if a person’s actual blood pressure is 134, and blood pressure is measured on a dangling arm, the reading could end up over 140, which is considered to be stage 2 hypertension.
“Klonopin, that’s the worst drug I’ve ever been on,” she said. “I’d rather be back addicted to Oxycontin than have to come down off Klonopin again.” “One psychiatrist told me to cut back to three glasses of wine a day and two Klonopin,” I said. He was an interesting fellow from Egypt who had his medical practice near my ...
Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [19] [20] as well as sexual dysfunction. [6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22]
[13] [42] Obtaining a laboratory test for benzodiazepine blood concentrations can be useful in patients presenting with CNS depression or coma of unknown origin. Techniques available to measure blood concentrations include thin layer chromatography , gas liquid chromatography with or without a mass spectrometer , and radioimmunoassay . [ 13 ]
Purvi Parikh, M.D., an allergist with Allergy & Asthma Network, recommends blowing one nostril at a time by putting a finger or pressure on one side of your nose, closing that nostril, and blowing ...