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Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously with a single query string and user interface. Entrez can efficiently retrieve related sequences , structures , and references.
The Entrez Global Query Cross-Database Search System is used at NCBI for all the major databases such as Nucleotide and Protein Sequences, Protein Structures, PubMed, Taxonomy, Complete Genomes, OMIM, and several others. [9] Entrez is both an indexing and retrieval system having data from various sources for biomedical research.
3D structure protein databases, Protein sequence databases MobiDB: Database of intrinsically disordered and mobile proteins: John Moult, Christine Orengo, Predrag Radivojac University of Padua: Italian Government database of intrinsic protein disorder annotation 3D structure protein databases, Protein sequence databases ModBase
By 1971, one of Meyer's programs, SEARCH, enabled researchers to remotely access information from the database to study protein structures offline. [9] SEARCH was instrumental in enabling networking, thus marking the functional beginning of the PDB. The Protein Data Bank was announced in October 1971 in Nature New Biology [10] as a joint ...
The GenBank sequence database is an open access, annotated collection of all publicly available nucleotide sequences and their protein translations. It is produced and maintained by the National Center for Biotechnology Information (NCBI; a part of the National Institutes of Health in the United States) as part of the International Nucleotide Sequence Database Collaboration (INSDC).
BLASTp, or Protein BLAST, is used to compare protein sequences. You can input one or more protein sequences that you want to compare against a single protein sequence or a database of protein sequences. This is useful when you're trying to identify a protein by finding similar sequences in existing protein databases. [18]
CDD content includes NCBI manually curated domain models and domain models imported from a number of external source databases (Pfam, SMART, COG, PRK, TIGRFAMs).What is unique about NCBI-curated domains is that they use 3D-structure information to explicitly define domain boundaries, align blocks, amend alignment details, and provide insights into sequence/structure/function relationships.
The Reference Sequence (RefSeq) database [1] is an open access, annotated and curated collection of publicly available nucleotide sequences (DNA, RNA) and their protein products. RefSeq was introduced in 2000.