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Serious side effects include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior in people under 25 years old, and an increased risk of bleeding. [2] Antidepressant discontinuation syndrome is less likely to occur with fluoxetine than with other antidepressants, but it still happens in many cases.
The relative risk of intracranial bleeding is increased, but the absolute risk is very low. [105] SSRIs are known to cause platelet dysfunction. [ 106 ] [ 107 ] This risk is greater in those who are also on anticoagulants, antiplatelet agents and NSAIDs (nonsteroidal anti-inflammatory drugs), as well as with the co-existence of underlying ...
The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. It is related in chemical structure to venlafaxine. Due to being an opioid, there is risk of abuse and addiction, but it does have less abuse potential, respiratory depression, and constipation compared to other opioids (hydrocodone, oxycodone ...
In a study comparing 32 antidepressants of all pharmacological classes, mirtazapine was one of the antidepressants most likely to cause nightmare disorder, sleepwalking, restless legs syndrome, night terrors and sleep paralysis. [55] Mirtazapine has been associated with an increased risk of death compared to other antidepressants in several ...
This technique may be used if your medication puts you at risk for withdrawal symptoms, which may occur when some antidepressants are stopped without a gradual taper. Taper and moderate switch.
However, increased side effects and abuse potential are potential concerns of these agents relative to their SSRI and SNRI counterparts. The SNDRIs are similar to non-selective monoamine oxidase inhibitors (MAOIs) such as phenelzine and tranylcypromine in that they increase the action of all three of the major monoamine neurotransmitters.
The FDA is recalling more than 7,000 bottles of the antidepressant duloxetine due to a possible ... daily intake limits every day for 70 years is not expected to have an increased risk of cancer." ...
Increased concentrations of nortriptyline may increase the risk for side effects, including anticholinergic and nervous system adverse effects, while decreased concentrations may reduce the drug's efficacy. [39] [40] [41] Individuals can be categorized into different types of CYP2D6 metabolizers depending on which genetic variations they carry ...