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In addition, factors such as rapid infusion, concurrent use of more than one drug known to prolong QT interval, diuretic treatment, electrolyte derangements (hypokalemia, hypomagnesemia, or hypocalcemia), advanced age, bradyarrhythmias, and female sex have all been shown to be risk factors for developing drug-induced QT prolongation. [2]
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).
Additionally, in clinical trials ranolazine slightly increased QT interval in some patients [13] and the FDA label contains a warning for doctors to beware of this effect in their patients. [10] The drug's effect on the QT interval is increased in the setting of liver dysfunction; thus it is contraindicated in persons with mild to severe liver ...
Prolonged QT interval (had an odds ratio for prolonging the QT interval over placebo of 0.17) [22] Sudden cardiac death; Syncope; Diabetic ketoacidosis; Restless legs syndrome; Hyponatraemia, low blood sodium. Jaundice, yellowing of the eyes, skin and mucous membranes due to an impaired ability of the body to clear bilirubin, a by product of ...
Drugs that prolong the QT interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, and some antipsychotics may increase the chance of ventricular dysrhythmias. TCAs may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. Side effects may also be enhanced by other ...
More severe side effects include low blood pressure, weakness, and allergic reactions. [3] It is unclear if use in pregnancy is safe for the fetus. [3] Pyridostigmine is an acetylcholinesterase inhibitor in the cholinergic family of medications. [3] It works by blocking the action of acetylcholinesterase and therefore increases the levels of ...
According to the FDA, sotalol should not be used in people with a waking heart rate lower than 50 beats per minute. [8] It should not be used in people with sick sinus syndrome, long QT syndrome, cardiogenic shock, uncontrolled heart failure, asthma or a related bronchospastic condition, or people with serum potassium below 4 meq/L. [8] It should only be used in people with a second and third ...
Concomitant use with drugs that both prolong the QT interval and are metabolized by CYP2D6 (e.g., thioridazine, pimozide); effects on QT interval may be increased; Concomitant use with MAOIs or use of MAOIs within 14 days; risk of serious, potentially fatal, drug interactions including serotonin syndrome; Heart failure