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The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
Sometimes, the term "precancer" is also used for carcinoma in situ, which is a noninvasive cancer that has not grown and spread to nearby tissue, unlike the invasive stage. As with other precancerous conditions, not all carcinoma in situ will become an invasive disease but is at risk of doing so.
Cervical cancer is a cancer arising from the cervix or in any layer of the wall of the cervix. [2] It is due to the abnormal growth of cells that can invade or spread to other parts of the body. [12]
The term carcinoma in situ may be used interchangeably with high-grade SIL. [8] Ductal carcinoma in situ of the breast is the most common precancer in women. Bowen's disease is a squamous carcinoma in situ of the skin. Colon polyps often contain areas of CIS that will almost always transform into colon cancer if left untreated.
In general, treatment can include surgical resection, [39] chemotherapy, [40] radiation therapy, [41] or immunotherapy. [42] Recent medical advances have improved our understanding of the genetic basis of childhood cancers. Treatment options are expanding, and precision medicine for childhood cancers is a rapidly growing area of research. [43]
After age 30 it was thought that women exposed prenatally, "DES daughters", were no longer at risk for the disease, but as they age into their 40s and 50, cases continue to be reported. [ 1 ] According to the Centers for Disease Control and Prevention (CDC), DES daughters should have a pap / pelvic exam every year because of their lifelong risk ...
The loop electrosurgical excision procedure (LEEP) is one of the most commonly used approaches to treat high grade cervical dysplasia (CIN II/III, HGSIL) and early stage cervical cancer discovered on colposcopic examination. In the UK, it is known as large loop excision of the transformation zone (LLETZ).
The cervix is divided into two parts based on the types of cells. The outer portion of the cervix is called the ectocervix, while the inner portion of the cervix is the endocervix. These two portions of the cervix have different types of cells. The area where the endocervix and ectocervix meet is known as the transformation zone.