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Phentolamine is marketed in the dental field as a local anesthetic reversal agent. Branded as OraVerse, it is a phentolamine mesylate injection designed to reverse the local vasoconstrictor properties used in many local anesthetics to prolong anesthesia.
Nonselective alpha blockers, such as phenoxybenzamine or phentolamine, can be used to mitigate this disease. Pheochromocytoma is a disease in which a catecholamine secreting tumor develops. [2] [20] Specifically, norepinephrine and epinephrine are secreted by these tumors, either continuously or intermittently. [21]
FDA-approved uses of these drugs include treating conditions like benign prostatic hyperplasia, hypertension, pheochromocytoma, extravasation management, and reversal of local anesthesia. [1] Common examples of alpha 1 blockers are Tamsulosin, Prazosin, Phentolamine, and Phenoxybenzamine. [1]
Two examples of competitive adrenergic antagonists are propranolol and phentolamine. Phentolamine is a competitive and nonselective α-adrenoreceptor antagonist. Propranolol is a β-adrenoreceptor antagonist. [8]
It triggers a series of responses after the body releases chemicals named noradrenaline and epinephrine. [1] These chemicals will act on adrenergic receptors , with subtypes Alpha-1 , Alpha-2 , Beta-1 , Beta-2 , Beta-3 , which ultimately allow the body to trigger a "fight-or-flight" response to handle external stress. [ 1 ]
Alpha-2 blockers (or α 2 blockers) are a subset of the alpha blocker class of drugs and are antagonists to the α 2 adrenergic receptor.They are mainly used in research, having found limited clinical application in human medicine.
Benign prostatic hyperplasia (BPH) is an enlarged prostate gland.Alpha-1 blockers are the most commonly used medicine to treat BPH. [6] Alpha-1 blockers are first line treatment for the symptoms of BPH in men.
Phenoxybenzamine is used as an anti-hypertensive due to its efficacy in reducing the vasoconstriction caused by epinephrine (adrenaline) and norepinephrine. Phenoxybenzamine forms a permanent covalent bond with adrenergic receptors.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261
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