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Midodrine, also known as 3,6-dimethoxy-β-hydroxy-N-aminoethanonyl-2-phenylethylamine, is a substituted phenethylamine derivative. [4] Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol. [19] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.
Heart rate variability visualized with R-R interval changes Electrocardiogram (ECG) recording of a canine heart that illustrates beat-to-beat variability in R–R interval (top) and heart rate (bottom). Heart rate variability (HRV) is the physiological phenomenon of variation in the time interval between heartbeats. It is measured by the ...
Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine. [1] [2] [3] It acts as a selective α 1-adrenergic receptor agonist. [1] [2] [3] Desglymidodrine is formed from midodrine via deglycination. [1] [2] [3]
Thanks to wearable devices, you can use all sorts of metrics to keep track of your health. You can check your weight, blood pressure, the number of steps you take, heart rate and more as you go ...
This natural variation is known as heart rate variability (HRV). However, certain cardiac conditions may cause the individual IBI values to become nearly constant, resulting in the HRV being nearly zero. This can happen, for example, during periods of exercise as the heart rate increases and the beats become regular.
The vagus nerve acts on the sinoatrial node, slowing its conduction and modulating vagal tone, via the neurotransmitter acetylcholine and downstream changes to ionic currents and calcium of heart cells. [4] Because of its effect on heart rate, and cardio health, vagal tone can be measured and understood by examining its correlation to heart ...
Reflex bradycardia is a bradycardia (decrease in heart rate) in response to the baroreceptor reflex, one of the body's homeostatic mechanisms for preventing abnormal increases in blood pressure. In the presence of high mean arterial pressure , the baroreceptor reflex produces a reflex bradycardia as a method of decreasing blood pressure by ...
Chronotropic effects (from chrono-, meaning time, and tropos, "a turn") are those that change the heart rate. Chronotropic drugs may change the heart rate and rhythm by affecting the electrical conduction system of the heart and the nerves that influence it, such as by changing the rhythm produced by the sinoatrial node. Positive chronotropes ...
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