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Phenol is a component in liquid–liquid phenol–chloroform extraction technique used in molecular biology for obtaining nucleic acids from tissues or cell culture samples. Depending on the pH of the solution either DNA or RNA can be extracted. Phenol is so inexpensive that it also attracts many small-scale uses.
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (−O H) bonded directly to an aromatic hydrocarbon group. [1] The simplest is phenol, C 6 H 5 OH. Phenolic compounds are classified as simple phenols or polyphenols based on the number of phenol units in the ...
[23] [24] The aromatic amino acid phenylalanine, synthesized in the shikimic acid pathway, is the common precursor of phenol containing amino acids and phenolic compounds. In plants, the phenolic units are esterified or methylated and are submitted to conjugation , which means that the natural phenols are mostly found in the glycoside form ...
Chemical structure of salicylic acid, a common phenolic acid. Phenolic acids or phenolcarboxylic acids are phenolic compounds and types of aromatic acid compounds. Included in that class are substances containing a phenolic ring and an organic carboxylic acid function (C6-C1 skeleton).
The first example of an oxidative phenol coupling in synthetic chemistry can be traced to Julius Löwe’s 1868 synthesis of ellagic acid, accomplished by heating gallic acid with arsenic acid. [8] In the synthesis of complex organic compounds, oxidative phenol couplings are sometimes employed.
Related compounds Related phenols: xylenols: Related compounds bromocresol green, cresol red: Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references
Sodium phenoxide is a moderately strong base. Acidification gives phenol: [5] PhOH ⇌ PhO − + H + (K = 10 −10) The acid-base behavior is complicated by homoassociation, reflecting the association of phenol and phenoxide. [6] Sodium phenoxide reacts with alkylating agents to afford alkyl phenyl ethers: [2]
In 1834, German chemist Friedlieb Ferdinand Runge discovered a phenol, also known as carbolic acid, which he derived in an impure form from coal tar.In August 1865, Joseph Lister applied a piece of lint dipped in carbolic acid solution to the wound of an eleven-year-old boy at Glasgow Royal Infirmary, who had sustained a compound fracture after a cart wheel had passed over his leg.