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The rapidity with which premature cell death can occur depends on the cell type and the degree and duration of the anoxia. Haematopoietic cells, in bone marrow, are sensitive to anoxia and are the first to die after reduction or removal of the blood supply. In anoxic conditions they usually die within 12 hours.
Many patients with MRONJ have successful outcomes after treatment [50], meaning that the local osteonecrosis is stopped, the infection is cleared, and the mucosa heals and once again covers the bone. The treatment the person receives depends on the severity of osteonecrosis of the jaw.
The hematopoietic cells are most sensitive to low oxygen and are the first to die after reduction or removal of the blood supply, usually within 12 hours. [2] Experimental evidence suggests that bone cells (osteocytes, osteoclasts, osteoblasts etc.) die within 12–48 hours, and that bone marrow fat cells die within 5 days. [2]
The current, more correct, term, osteomyelitis of the jaws, differentiates the condition from the relatively recent and better known phenomenon of bisphosphonate-caused osteonecrosis of the jaws. The latter is found primarily in post-menopausal women given bisphosphonate medications, usually against osteoporosis .
Osteoradionecrosis (ORN) is a serious complication of radiation therapy in cancer treatment where radiated bone becomes necrotic and exposed. [1] ORN occurs most commonly in the mouth during the treatment of head and neck cancer, and can arise over 5 years after radiation. [2]
Spontaneous osteonecrosis of the knee is the result of vascular arterial insufficiency to the medial femoral condyle of the knee resulting in necrosis and destruction of bone. It is often unilateral and can be associated with a meniscal tear .
Dysbaric osteonecrosis or DON is a form of avascular necrosis where there is death of a portion of the bone that is thought to be caused by nitrogen (N 2) embolism (blockage of the blood vessels by a bubble of nitrogen coming out of solution) in divers. [1] Although the definitive pathologic process is poorly understood, there are several ...
Chandler's disease, also known as idiopathic avascular osteonecrosis of the femoral head (ANFH or ONFH), is a rare condition in which the bone cells in the head of the femur (FH) die due to lack of blood. This disease is caused when blood flow is reduced to the part of a bone near a joint.