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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.
The Vietnamese Wikipedia initially went online in November 2002, with a front page and an article about the Internet Society.The project received little attention and did not begin to receive significant contributions until it was "restarted" in October 2003 [3] and the newer, Unicode-capable MediaWiki software was installed soon after.
Vietnamese (tiếng Việt) is an Austroasiatic language spoken primarily in Vietnam where it is the official language. It belongs to the Vietic subgroup of the Austroasiatic language family. [5] Vietnamese is spoken natively by around 85 million people, [1] several times as many as the rest of the Austroasiatic family combined. [6]
Sóc Trăng (362,029 people, constituting 30.18% of the province's population and 27.43% of all Khmer in Vietnam), Trà Vinh (318,231 people, constituting 31.53% of the province's population and 24.11% of all Khmer in Vietnam), Kiên Giang (211,282 people, constituting 12.26% of the province's population and 16.01% of all Khmer in Vietnam), An ...
Tiến lên (Vietnamese: tiến lên, tiến: advance; lên: to go up, up; literally: "go forward"; also Romanized Tien Len) is a shedding-type card game originating in Vietnam. [1] It may be considered Vietnam's national card game, and is common in communities where Vietnamese migration has occoured.
On 12 February, a VC ambush had killed nine Marines from Company B, 1st Battalion, 7th Marines. [2]: 345 A five-man Marine "hunter-killer" patrol led by Lance Corporal Randell D. Herrod, who had been in the country for seven months, alongside Private Thomas R. Boyd Jr., PFC Samuel G. Green, PFC Michael A. Schwarz and Lance Corporal Michael S. Krichten had been in Vietnam for only a month, was ...
Vietnamese uses 22 letters of the ISO basic Latin alphabet.The four remaining letters are not considered part of the Vietnamese alphabet although they are used to write loanwords, languages of other ethnic groups in the country based on Vietnamese phonetics to differentiate the meanings or even Vietnamese dialects, for example: dz or z for southerner pronunciation of v in standard Vietnamese.