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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to target a particular molecular structure; biological (bDMARD) can be further separated into original and biosimilar DMARDs (boDMARDs and bsDMARDs)
The most commonly used agent is methotrexate with other frequently used agents including sulfasalazine and leflunomide. [8] Leflunomide is effective when used from 6–12 months, with similar effectiveness to methotrexate when used for 2 years. [119] Sulfasalazine also appears to be most effective in the short-term treatment of rheumatoid ...
This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.
In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders.
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Leflunomide. PubMed provides review articles from the past five years (limit to free review articles)
Leflunomide is an isoxazole-derivative drug. Examples of AAS containing the isoxazole ring include danazol and androisoxazole. A number of pesticides are isoxazoles. [10] Isoxaben is an example of an isoxazole used as a herbicide.
Arava, a brand name for the antirheumatic drug leflunomide Arava Shahaf (born 1990), Israeli female footballer Aravah (Sukkot) , a willow branch, one of the four species used on the Jewish holiday of Sukkot