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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
Similar to other protocols, the method tests for cholesterol levels, blood pressure, and diabetes mellitus, as well as factors not included in other current protocols, including systemic inflammation, vitamin D deficiency, insulin resistance, elevated levels of lipoprotein(a), and genetic risks, to identify potential root causes of arterial plaque.
A meta-analysis reported a sensitivity of 76% and specificity of 70% for bacteremia. [55] A 2018 systematic review comparing PCT and C-reactive protein (CRP) found PCT to have a sensitivity of 80% and a specificity of 77% in identifying septic patients. In the study, PCT outperformed CRP in diagnostic accuracy of predicting sepsis. [56]
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
A negative result in a test with high sensitivity can be useful for "ruling out" disease, [4] since it rarely misdiagnoses those who do have the disease. A test with 100% sensitivity will recognize all patients with the disease by testing positive. In this case, a negative test result would definitively rule out the presence of the disease in a ...
They use the sensitivity and specificity of the test to determine whether a test result usefully changes the probability that a condition (such as a disease state) exists. The first description of the use of likelihood ratios for decision rules was made at a symposium on information theory in 1954. [ 1 ]
C-reactive protein, an acute phase protein produced by the liver; cAMP receptor protein (catabolite gene activator protein) Cysteine-rich protein, a class of small proteins; Carbon-fiber-reinforced polymers; Chinese restaurant process, in probability theory; Chronic relapsing polyneuropathy, an acquired disorder of the nervous system
A blood test is a laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick. Multiple tests for specific blood components, such as a glucose test or a cholesterol test , are often grouped together into one test panel called a blood panel or blood work .