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Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
In cancer cells, major changes in gene expression increase glucose uptake to support their rapid growth. Unlike normal cells, which produce lactate only when oxygen is low, cancer cells convert much of the glucose to lactate even in the presence of adequate oxygen. This is known as the “Warburg Effect.”
A gas evolution reaction is a chemical reaction in which one of the end products is a gas such as oxygen or carbon dioxide. [ 1 ] [ 2 ] Gas evolution reactions may be carried out in a fume chamber when the gases produced are poisonous when inhaled or explosive.
The international pictogram for oxidizing chemicals. Dangerous goods label for oxidizing agents. An oxidizing agent (also known as an oxidant, oxidizer, electron recipient, or electron acceptor) is a substance in a redox chemical reaction that gains or "accepts"/"receives" an electron from a reducing agent (called the reductant, reducer, or electron donor).
Oxidizing acids, being strong oxidizing agents, can often oxidize certain less reactive metals, in which the active oxidizing agent is not H + ions. For example, copper is a rather unreactive metal, and has no reaction with concentrated hydrochloric acid.
The use of zinc chloride as a flux, sometimes in a mixture with ammonium chloride (see also Zinc ammonium chloride), involves the production of HCl and its subsequent reaction with surface oxides. Zinc chloride forms two salts with ammonium chloride: [NH 4] 2 [ZnCl 4] and [NH 4] 3 [ZnCl 4]Cl, which decompose on heating liberating HCl, just as ...
Some polymerization reactions such as the setting of epoxy resin; The reaction of most metals with halogens or oxygen; Nuclear fusion in hydrogen bombs and in stellar cores (to iron) Nuclear fission of heavy elements; The reaction between zinc and hydrochloric acid; Respiration (breaking down of glucose to release energy in cells)
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).