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Bronchopulmonary dysplasia (BPD; part of the spectrum of chronic lung disease of infancy) is a chronic lung disease which affects premature infants. Premature (preterm) infants who require treatment with supplemental oxygen or require long-term oxygen are at a higher risk. [ 1 ]
Medical diagnosis of pulmonary hypoplasia in utero may use imaging, usually ultrasound or MRI. [12] [13] The extent of hypoplasia is a very important prognostic factor. [14]One study of 147 fetuses (49 normal, 98 with abnormalities) found that a simple measurement, the ratio of chest length to trunk length, was a useful predictor of postnatal respiratory distress. [15]
The lungs may also appear hyperinflated. [5] It is a diagnosis of exclusion as it is a benign condition that can have symptoms and signs similar to more serious syndromes, such as respiratory distress or meconium aspiration. [2] In distinction to transient tachypnea, respiratory distress syndrome is more common in premature infants.
The lungs of infants with respiratory distress syndrome are developmentally deficient in a material called surfactant, which helps prevent the collapse of the terminal air spaces (the future site of alveolar development) throughout the normal cycle of inhalation and exhalation. This deficiency of surfactant is related to inhibition from the ...
Either one side of the lung fails completely, leading to pulmonary aplasia, or one side of the lung is underdeveloped, leading to dysplasia or hypoplasia. [11] These defects occur during the early stage of lung development, although not as early as bilateral pulmonary agenesis, when respiratory primordium bifurcates into right and left ...
Antenatal steroids have also been shown to have definite beneficial effect in treating the condition of preterm premature rupture of membranes (PPROM). [8] Similar to its effects on preterm birth, research evidence suggests that the administration of antenatal steroids to patients with PPROM reduces risks of neonatal mortality, intraventricular hemorrhage and respiratory distress syndrome.
The premature babies, who weigh less than 1.5 kg (3.3 pounds) each and in some cases only 700 or 800 grammes, should be in incubators where the temperature and humidity can be regulated according ...
Hypoxia is a common complication of preterm birth in newborn infants. Because the lungs develop late in pregnancy, premature infants frequently possess underdeveloped lungs. To improve blood oxygenation, infants at risk of hypoxia may be placed inside incubators that provide warmth, humidity, and supplemental oxygen.