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  2. N-Nitrosodimethylamine - Wikipedia

    en.wikipedia.org/wiki/N-Nitrosodimethylamine

    At high doses, it is a "potent hepatotoxin that can cause fibrosis of the liver" in rats. [9] The induction of liver tumors in rats after chronic exposure to low doses is well documented. [ 10 ] Its toxic effects on humans are inferred from animal experiments, but not well-established experimentally.

  3. Nitrosamine - Wikipedia

    en.wikipedia.org/wiki/Nitrosamine

    In 1956, two British scientists, John Barnes and Peter Magee, reported that a simple member of the large class of N-nitrosamines, dimethylnitrosamine, produced liver tumours in rats. Subsequent studies showed that approximately 90% of the 300 nitrosamines tested were carcinogenic in a wide variety of animals. [15]

  4. Tobacco-specific nitrosamines - Wikipedia

    en.wikipedia.org/wiki/Tobacco-specific_nitrosamines

    NNK and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent systemic lung carcinogens in rats. Tumors of the nasal cavity, liver, and pancreas are also observed in NNK- or NNAL-treated rats. NNN is an effective esophageal carcinogen in the rat, [4] and induces respiratory tract tumors in mice

  5. Nitrosamine formation during digestion - Wikipedia

    en.wikipedia.org/wiki/Nitrosamine_formation...

    The effects of nitroso compounds vary dramatically across the gastrointestinal tract, and with diet. Nitroso compounds present in stool do not induce nitrosamine formation, because stool has neutral pH. [7] [8] Stomach acid catalyzes nitrosamine compound formation and is the main location of the reaction during digestion. [9]

  6. Cats, finches and rats: NHSPCA overwhelmed by animals in need ...

    www.aol.com/cats-finches-rats-nhspca-overwhelmed...

    The shelter took in 36 cats, 30 finches and 30 rats in three separate incidents in the past four days. Officials said the new arrivals have added to the burden of lagging adoptions and recent ...

  7. Nitrosation and nitrosylation - Wikipedia

    en.wikipedia.org/wiki/Nitrosation_and_nitrosylation

    Indeed, (meta)stable nitrosation products (alkyl nitrites or nitrosamines) can also nitrosate under such conditions; and the equilibria can be driven in any desired direction. Absent a driving force, thionitrosos form out of nitrosamines, which form out of nitrite esters, which form out of nitrous acid. [3]

  8. Animal testing on rodents - Wikipedia

    en.wikipedia.org/wiki/Animal_testing_on_rodents

    Rodents such as rats are the most common model in researching effects of cardiovascular disease, as the effects on rodents mimic those in humans. [12] Rats have also been used as tools in research to try to find if there is a difference in the effects of cocaine on adults versus adolescents. [13]

  9. Louisville nursing homes closing because of rats ‘as big as ...

    www.aol.com/news/louisville-nursing-homes...

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