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Contrast CT of a patient with brain metastases from breast cancer, before (left) and after (right) injection of iodinated contrast.. Iodinated contrast is a form of water-soluble, intravenous radiocontrast agent containing iodine, which enhances the visibility of vascular structures and organs during radiographic procedures.
Parenchymal changes of the lung can often be evaluated adequately without the use of intravenous contrast. CT pulmonary angiogram: 20 ml [notes 2] 17 ml [notes 2] 15 ml [notes 2] Minimal amount when using specific low-contrast protocol. [notes 2] CT of abdomen: Overall: 70 ml [11] 60 ml [11] 55 ml [11] Liver: 55 ml [notes 3] 45 ml [notes 3] 40 ...
Retrograde pyelography is generally done when an intravenous excretory study (intravenous pyelogram or contrast CT scan) cannot be done because of renal disease or allergy to intravenous contrast. Relative contraindications include the presence of infected urine, pregnancy (because of radiation), or allergy to the contrast. [13]
Type IV hypersensitivity, in the Gell and Coombs classification of allergic reactions, often called delayed-type hypersensitivity, is a type of hypersensitivity reaction that can take a day or more to develop. [1] Unlike the other types, it is not humoral (not antibody-mediated) but rather is a type of cell-mediated response.
Iodinated contrast contains iodine.It is the main type of radiocontrast used for intravenous administration.Iodine has a particular advantage as a contrast agent for radiography because its innermost electron ("k-shell") binding energy is 33.2 keV, similar to the average energy of x-rays used in diagnostic radiography.
A reaction may occur whenever iodine contrast is injected. These reactions range in severity and it is difficult to predict if they will occur. With the current practice of using low-osmolar contrast these adverse reactions only occur in ~0.1% of cases. [4] The severity of the reaction can be broken down into three groups:
Type IV hypersensitivity reactions are, to some extent, normal physiological events that help fight infections, and dysfunction in this system can predispose to multiple opportunistic infections. Adverse events can also occur due to these reactions when an undesirable interaction between the immune system and an allergen happens.
Contrast-enhanced ultrasound is regarded as safe in adults, comparable to the safety of MRI contrast agents, and better than radiocontrast agents used in contrast CT scans. The more limited safety data in children suggests that such use is as safe as in the adult population. [2]