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Povidone-iodine (PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. [ 1 ] [ 2 ] It may be used both to disinfect the hands of healthcare providers and the skin of the person they are caring for. [ 2 ]
ATC code D08 Antiseptics and disinfectants is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Medical iodophor (Chinese povidone-iodine solution) An iodophor is a preparation containing iodine complexed with a solubilizing agent, such as a surfactant or water-soluble polymers such as povidone (forming povidone-iodine), [1] [2] The result is a water-soluble material that releases free iodine when in solution.
Iodine is a chemical element with many uses in medicine, depending on the form. Elemental iodine and iodophors are topical antiseptics. [2] Iodine, in non-elemental form, functions as an essential nutrient in human biology (see iodine in biology). [3] Organic compounds containing iodine are also useful iodinated contrast agents in X-ray imaging ...
The specialist then sterilizes the eye and the surrounding area, often with povidone-iodine (PVP-I) solution, to prevent any infection in the injected site. [22] [31] Aqueous chlorhexidine is used instead in case of adverse effects to povidone-iodine. [23] Next, an eyelid speculum is placed to retract the eyelids and thus hold the eye open.
PVP is a frequently used binder in pharmaceutical tablet formulations. [5] Pharmacokinetic studies in humans and various laboratory animal models indicate no to very little systemic absorption of PVP following oral administration. [6] PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. [7]
Iodine, especially in the form of povidone-iodine, is widely used because it is well tolerated; does not negatively affect wound healing; leaves a deposit of active iodine, thereby creating the so-called "remnant", or persistent effect; and has wide scope of antimicrobial activity.
Figure 1.0 - Basic anatomical features of the human eye. Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. [1]