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Metoclopramide is a medication used to treat nausea, vomiting, gastroparesis, and gastroesophageal reflux disease. [5] It is also used to treat migraine headaches. [6] Common side effects include feeling tired, diarrhea, akathisia, and tardive dyskinesia. More serious side effects include neuroleptic malignant syndrome and depression. [5]
Haloperidol (limited in usefulness by extra-pyramidal and sedative side-effects) Alizapride; Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil) Chlorpromazine (Use limited by sedating properties) Metoclopramide; NK1 receptor antagonist. Aprepitant (Emend) is a commercially available NK1 receptor antagonist
In the 1970s, John Fozard found that metoclopramide and cocaine were weak antagonists at the 5-HT 3 (5-HT-M) receptor. Fozard and Maurice Gittos later synthesized MDL 72222, the first potent and truly selective 5-HT 3 receptor antagonist. [35] [36] The antiemetic effects of metoclopramide were found to be partially because of its serotonin ...
Due to the blockade of D 2 receptors in the central nervous system, D 2 receptor antagonists like metoclopramide and antipsychotics can also produce a variety of additional side effects including drowsiness, akathisia, restlessness, insomnia, lassitude, fatigue, extrapyramidal symptoms, dystonia, Parkinsonian symptoms, tardive dyskinesia, and ...
The combination of metoclopramide to the paracetamol has been shown to enhance the analgesia relief when used to treat the pain of arthritis. [ 4 ] Whilst the individual component drugs may be prescribed individually, as a combination, it is only available as the branded Paramax preparation in the UK. [ 5 ]
It can also entail a binge drinking session of five or more drinks for men and four or more drinks for women. On the flip side, a moderate, healthier intake of alcohol is considered to be, at most ...
Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...
The name "belladonna", Italian for "beautiful lady", is thought to derive from one of the antimuscarinic effects of these alkaloids: they were used by women for cosmetic purposes, to promote dilation of the pupils. [2] Muscarinic antagonist effects and muscarinic agonist effects counterbalance each other for homeostasis.