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Soluble guanylate cyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class medication was riociguat, approved in 2013 for pulmonary hypertension. [1] [2] They have also been investigated for hypertension, systemic sclerosis, and sickle cell disease. [3] [1]
Although these effects are unpleasant and harmful, they were, along with akathisia, considered a reliable sign that the drug was working. [31] These terms have been largely replaced by the term "antipsychotic" in medical and advertising literature, which refers to the medication's more-marketable effects. [33]
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Superplasticizers (SPs), also known as high range water reducers, are additives used for making high-strength concrete or to place self-compacting concrete. Plasticizers are chemical compounds enabling the production of concrete with approximately 15% less water content. Superplasticizers allow reduction in water content by 30% or more.
The side effects reportedly associated with the various atypical antipsychotics vary and are medication-specific. Generally speaking, atypical antipsychotics are widely believed to have a lower likelihood for the development of tardive dyskinesia than the typical antipsychotics. However, tardive dyskinesia typically develops after long-term ...
Muscarinic antagonist effects and muscarinic agonist effects counterbalance each other for homeostasis. Certain muscarinic antagonists can be classified into either long-acting muscarinic receptor antagonists ( LAMA s) or short-acting muscarinic receptor antagonists ( SAMA s), depending on when maximum effect occurs and for how long the effect ...
When it comes to injectibal drugs like Ozempic and Wegovy, there are some broad side effects that apply to all injectibals — like swelling, redness or other discomfort at the injection site ...
Unfortunately, these medications are associated with significant neurotoxicities. Psychiatric medications carry risk for neurotoxic adverse effects. The occurrence of neurotoxic effects can potentially reduce drug compliance. Some adverse effects can be treated symptomatically by using adjunct medications such as anticholinergics (antimuscarinics).
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