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Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
Due to the fact B. pertussis is only found in humans and shows little genetic variation from the other Bordetella species, it is thought that it was derived from a common ancestor in recent years. B. parapertussis can affect both humans and other mammals, primarily sheep. Similar to B. pertussis, it causes whooping cough in babies. Yet, when ...
What is whooping cough? According to the Centers for Disease Control. whooping cough, also known as pertussis, is a highly contagious respiratory illness caused by the bacteria Bordetella pertussis.
Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein.The protein consists of three domains: from the N-terminus up to roughly residue 400, there is an adenylate-cyclase domain; between residues 500 and 700, there is a hydrophobic domain; and from residue 1000 to the C-terminus, there are calcium binding repeats.
The CDC stated that the first signs of whooping cough are the same signs you would see in a common cold - runny nose, sneezing, etc. But then the symptoms get worse. Here are some symptoms of the ...
Whooping cough cases are skyrocketing in New York City, according to shocking new data that emerges as many unvaccinated migrants continue to pour into the Big Apple. NYC whooping cough cases ...
Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and released in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. [1] CyaA plays a particular role in the early phases of airway colonization.
Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis, [1] Vibrio fischeri (as a symbiosis chemical), [2] and Neisseria gonorrhoeae (among other peptidoglycan-derived cytotoxins it produces). [3]