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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
As ovarian cancer is rarely symptomatic until an advanced stage, [42] regular pre-emptive screening is a particularly important tool for avoiding the late stage at which most patients present. However, A 2011 US study found that transvaginal ultrasound and cancer marker CA125 screening did not reduce ovarian cancer mortality. [ 43 ]
CA-125 levels appear to fall during endometriosis treatment, but it has not shown a correlation with disease response. [ 121 ] Another review in 2011 identified several putative biomarkers upon biopsy, including findings of small sensory nerve fibers or defectively expressed β3 integrin subunit. [ 123 ]
Medroxyprogesterone acetate; Clinical data; Pronunciation / m ɛ ˌ d r ɒ k s i p r oʊ ˈ dʒ ɛ s t ər oʊ n ˈ æ s ɪ t eɪ t / me-DROKS-ee-proh-JES-tər-ohn ASS-i-tayt [1] Trade names: Depo-Provera, others
The CA-125 marker in children and adolescents can be frequently elevated even in absence of malignancy and conservative management should be considered. Polycystic ovarian syndrome involves the development of multiple small cysts in both ovaries due to an elevated ratio of leutenizing hormone to follicle stimulating hormone , typically more ...
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Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium (modified peritoneum) or from ectopic endometrial or fallopian tube (tubal) tissue.
Diseases and Disorders of the Male Reproductive System 707 - 730 13 Diseases and Disorders of the Female Reproductive System 734 - 761 14 Pregnancy, Childbirth And Puerperium 765 - 782 15 Newborn And Other Neonates (Perinatal Period) 789 - 795 16 Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders 799 - 816 17