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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
High cortisol levels can cause anxiety and irritability because the hormone is involved in your fight-or-flight response. Digestive issues. Cortisol influences digestion and can lead to bloating ...
Another cause for Cushing's syndrome is adrenocortical carcinoma. This is a rare form of cancer with an incidence of 1-2 per million people annually. About 60% of these cancers produce hormones, with cortisol being the most frequent. Most patients present in an advanced disease state and the outcome is dismal. [7]
In addition to the severe hormonal effects related to increased blood cortisol levels, the large tumor can compress adjacent structures. [7] These tumors can compress the nerves that carry information from the eyes, causing a decrease in peripheral vision. [citation needed] Glaucoma and cataracts also may occur in Cushing's syndrome. In ...
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Unwanted weight loss of more than 5% within 6 months. [2] [19] For people with a BMI of less than 20 kg/m 2, weight loss of more than 2%. [2] [19] [27] For people with sarcopenia, weight loss of more than 2%. [2] [19] [27] New ways to score and stage cachexia are being explored, particularly in people with advanced cancer. [19]
Purdy adds that while inflammation can be seen in the face as a result of too much cortisol, “this is just one of the symptoms, so it is not necessarily the primary cause.”
[3] [4] Cancer can be difficult to diagnose because its signs and symptoms are often nonspecific, meaning they may be general phenomena that do not point directly to a specific disease process. [5] In medicine, a sign is an objective piece of data that can be measured or observed, as in a high body temperature (fever), a rash, or a bruise. [6]