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Cefoperazone contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain.As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse effect), due to inhibition of aldehyde dehydrogenase.
Cefoperazone/sulbactam is a combination drug used as an antibiotic. It is effective for the treatment of urinary tract infections . [ 2 ] It contains cefoperazone , a β-lactam antibiotic , and sulbactam , a β-lactamase inhibitor , which helps prevent bacteria from breaking down cefoperazone.
[15] [16] These include latamoxef , cefmenoxime, cefoperazone, cefamandole, cefmetazole, and cefotetan. This is thought to be due to the methylthiotetrazole side-chain of these cephalosporins, which blocks the enzyme vitamin K epoxide reductase (likely causing hypothrombinemia) and aldehyde dehydrogenase (causing alcohol intolerance). [ 17 ]
The combination cefoperazone/sulbactam (Sulperazon) is available in many countries but not in the United States. [ 4 ] The co-packaged combination sulbactam/durlobactam was approved for medical use in the United States in May 2023.
Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic.The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.
In the intervening months, Trump's allies aggressively lobbied senators who appeared to be on the fence, at times threatening to primary them if they stood in the way of his nominees.
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Olivia Gadecki and John Peers combined for a 3-6, 6-4, 10-6 victory over John-Patrick Smith and Kimberly Birrell on Friday to win the first all-Aussie Australian Open mixed doubles final since 1967.