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A photo of human embryonic stem cells (the cell colonies in the center). Spindle cells surrounding the stem cell colony are MEFs. Mouse Embryonic Fibroblasts (MEFs) are a type of fibroblast prepared from mouse embryo. MEFs show a spindle shape when cultured in vitro, a typical feature of fibroblasts. The MEF is a limited cell line.
Unlike the epithelial cells lining the body structures, fibroblasts do not form flat monolayers and are not restricted by a polarizing attachment to a basal lamina on one side, although they may contribute to basal lamina components in some situations (e.g. subepithelial myofibroblasts in intestine may secrete the α-2 chain-carrying component ...
MEF2, Myocyte Enhancer Factor 2, is a transcription factor with four specific numbers such as MEF2A, B, C, and D. Each MEF2 gene is located on a specific chromosome. MEF2 is known to be involved in the development and the looping of the heart (Chen) MEF2 is necessary for myocyte differentiation and gene activation (Black).
Most animal cells have one MTOC during interphase, usually located near the nucleus, and generally associated closely with the Golgi apparatus. The MTOC is made up of a pair of centrioles at its center, and is surrounded by pericentriolar material (PCM) that is important for microtubule nucleation. Microtubules are anchored at the MTOC by their ...
The nuclear envelope, also known as the nuclear membrane, [1] [a] is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material. The nuclear envelope consists of two lipid bilayer membranes: an inner nuclear membrane and an outer nuclear membrane. [ 4 ]
Predominately found in transformed cancer cells, the prevalence is less than 5% in normal cell lines, but 15-100% in cancer cell lines. [6] The PNC is directly proportional to metastasis as well as linked to malignancy. [1] Thus, it is being further researched in its potential to be a biomarker for cancer.
4207 n/a Ensembl ENSG00000064489 n/a UniProt Q02080 n/a RefSeq (mRNA) NM_005919 n/a RefSeq (protein) NP_001139257 NP_001354211 NP_005910.1 n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Myocyte enhancer binding factor 2B (MEF2B) is a transcription factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D. However, MEF2B is distant from the other three ...
These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these primitive reticulum cells, namely the hemocytoblast. At this time several developing blood cell lines are available, like erythropoiesis and thrombopoiesis.