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Vinpocetine does not fully support a benefit in either dementia or stroke. [12] [9] [13] As of 2003, three controlled clinical trials had tested "older adults with memory problems". [14] Vinpocetine has also been studied for the prevention and recovery of acquired hearing loss in a phase II, longitudinal and prospective open clinical study on ...
Vinpocetine is a synthetic derivative of vincamine used for cerebrovascular diseases and as dietary supplement. [4] Vincamine derivatives have been also studied as anti addictive [ 5 ] and antidiabetic [ 6 ] agents.
Nicergoline, sold under the brand name Sermion among others, is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Internationally it has been used for frontotemporal dementia as well as early onset in Lewy body dementia and Parkinson's dementia.
When examining the cost-effectiveness of statin use in older adults, the researchers report that statins were cost-effective, with the cost per quality-adjusted life years gained below £3,502 ...
We found the best technology for adults over 65 at CES this year. From AI aids to ‘aging in place’ smart home solutions, the annual tech show kept older users in mind.
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
Vinpocetine inhibits differently the various subtypes of PDE1 (IC 50 from 8 to 50 μm) and it is also able to inhibit PDE7B. It can not be used as a specific tool to investigate the functional role of PDE1 due to its direct activator effects on BK (Ca) channels. [1] Vinpocetine crosses the blood–brain barrier and is taken up by cerebral tissue.
Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These compounds include vinblastine, vincristine, vindesine , and vinorelbine. Additional researched vinca alkaloids include vincaminol , vineridine , and vinburnine .