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Vinpocetine does not fully support a benefit in either dementia or stroke. [12] [9] [13] As of 2003, three controlled clinical trials had tested "older adults with memory problems". [14] Vinpocetine has also been studied for the prevention and recovery of acquired hearing loss in a phase II, longitudinal and prospective open clinical study on ...
Vinpocetine is a synthetic derivative of vincamine used for cerebrovascular diseases and as dietary supplement. [4] Vincamine derivatives have been also studied as anti addictive [ 5 ] and antidiabetic [ 6 ] agents.
The side effects of nicergoline are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness. [6] At high drug dosages, bradycardia, increased appetite, agitation, diarrhea and perspiration were reported. Most of the available literature suggests that the side effects of nicergoline are mild and transient. [2]
Vinpocetine inhibits differently the various subtypes of PDE1 (IC 50 from 8 to 50 μm) and it is also able to inhibit PDE7B. It can not be used as a specific tool to investigate the functional role of PDE1 due to its direct activator effects on BK (Ca) channels. [1] Vinpocetine crosses the blood–brain barrier and is taken up by cerebral tissue.
The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, [1] including catharanthine and vindoline [2] and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine [3] and vincristine, [4] all of which can be obtained from the plant.
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
"Numerous clinical studies have demonstrated the safety of vinpocetine during long-term administration. It has not been shown to change laboratory tests or produce allergic symptoms. Furthermore, no serious drug-drug interactions have been reported." [2] Wikipedia is meant to gather the best information possible and summarize it for readers.
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...