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Rhabdomyolysis may cause kidney failure by several mechanisms. The most important is the accumulation of myoglobin in the kidney tubules. [10] [11] [13] Normally, the blood protein haptoglobin binds circulating myoglobin and other heme-containing substances, but in rhabdomyolysis the quantity of myoglobin exceeds the binding capacity of ...
13350 Ensembl ENSG00000185000 ENSG00000285482 ENSMUSG00000022555 UniProt O75907 Q9Z2A7 RefSeq (mRNA) NM_012079 NM_010046 RefSeq (protein) NP_036211 NP_034176 Location (UCSC) Chr 8: 144.31 – 144.33 Mb Chr 15: 76.39 – 76.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Diacylglycerol O -acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene. Function This gene ...
The myoglobin is filtered by the kidneys, but is toxic to the renal tubular epithelium and so may cause acute kidney injury. [32] It is not the myoglobin itself that is toxic (it is a protoxin), but the ferrihemate portion that is dissociated from myoglobin in acidic environments (e.g., acidic urine, lysosomes). [citation needed]
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Exertional rhabdomyolysis, the exercise-induced muscle breakdown that results in muscle pain/soreness, is commonly diagnosed using the urine myoglobin test accompanied by high levels of creatine kinase (CK). Myoglobin is the protein released into the bloodstream when skeletal muscle is broken down. The urine test simply examines whether ...
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of kidney problems, it can occlude the kidneys' filtration system leading to acute tubular necrosis and acute kidney injury. Other causes of myoglobinuria include: McArdle's disease
The differential diagnosis can be complicated somewhat if the person exhibits only vomiting or diarrhea (rather than both). [1] Appendicitis may present with vomiting, abdominal pain, and a small amount of diarrhea in up to 33% of cases. [1] This is in contrast to the large amount of diarrhea that is typical of gastroenteritis. [1]
The Bruce effect, or pregnancy block, [1] [2] is the tendency for female rodents to terminate their pregnancies following exposure to the scent of an unfamiliar male. [3] The effect was first noted in 1959 by Hilda M. Bruce, [4] and has primarily been studied in laboratory mice (Mus musculus). [1]