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Mod release Standalone Notes 0 A.D. Age of Empires II: 2000 2010 April 2 The standalone version is under development by Wildfire Games and using the Pyrogenesis engine. Alien Swarm: Unreal Tournament 2004: 2004 May 28 2010 July 19 [1] The standalone version was developed by Valve and ported to the Source engine. Angels Fall First: Planetstorm
Terraria (/ t ə ˈ r ɛər i ə / ⓘ tə-RAIR-ee-ə [1]) is a 2011 action-adventure sandbox game developed by Re-Logic. The game was first released for Windows and has since been ported to other PC and console platforms.
Entamoeba histolytica is an anaerobic parasitic amoebozoan, part of the genus Entamoeba. [1] Predominantly infecting humans and other primates causing amoebiasis, E. histolytica is estimated to infect about 35-50 million people worldwide. [1] E. histolytica infection is estimated to kill more than 55,000 people each year. [2]
Amoebiasis is present all over the world, [6] though most cases occur in the developing world. [7] About 480 million people are currently infected with about 40 million new cases per year with significant symptoms. [2] [8] This results in the death of between 40,000–100,000 people a year. [4] The first case of amoebiasis was documented in 1875.
[1] [10] Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. [2] [6] [11] Complications may include dehydration. [3] The cause of dysentery is usually the bacteria from genus Shigella, in which case it is known as shigellosis, or the amoeba Entamoeba histolytica; then it is called amoebiasis. [1]
E. histolytica infections occur in both the intestine and (in people with symptoms) in tissue of the intestine and/or liver. [2] As a result, both tissue and luminal drugs are needed to treat the infection, one for each location.
The usage of conventional therapeutics to treat amoebiasis if often linked with substantial side effects, a threat to the efficacy of these therapeutics, further worsened by the development of drug resistance in the parasite. [20] Amoebic meningoencephalitis and keratitis is a brain-eating amoeba caused by free-living Naeglaria and Acanthomoeba.
It is an antimicrobial used to treat intestinal parasitic infections such as cryptosporidiosis [8] and amoebiasis, [9] and other diseases such as leishmaniasis. [10] Paromomycin was demonstrated to be effective against cutaneous leishmaniasis in clinical studies in the USSR in the 1960s, and in trials with visceral leishmaniasis in the early 1990s.