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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Dantrolene sodium, the only available medical treatment for malignant hyperthermia The current treatment of choice is the intravenous administration of dantrolene , the only known antidote, discontinuation of triggering agents, and supportive therapy directed at correcting hyperthermia, acidosis, and organ dysfunction.
The hydantoin derivative dantrolene is a spasmolytic agent with a unique mechanism of action outside of the CNS. It reduces skeletal muscle strength by inhibiting the excitation-contraction coupling in the muscle fiber.
There is no simple, straightforward test to diagnose the condition. When MH develops during a procedure, treatment with dantrolene sodium is usually initiated; dantrolene and the avoidance of suxamethonium administration in susceptible people have markedly reduced the mortality from this condition.
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Dantrolene has been used when needed to reduce muscle rigidity, and dopamine pathway medications such as bromocriptine have shown benefit. [44] Dantrolene may act centrally on thermoregulatory pathways to lower the temperature. [7] Dantrolene also inhibits calcium release from the muscle sarcoplasmic reticulum to cause muscle relaxation. [7]
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