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Undifferentiated pleomorphic sarcoma (UPS), also termed pleomorphic myofibrosarcoma, [1] high-grade myofibroblastic sarcoma, and high-grade myofibrosarcoma, [2] is characterized by the World Health Organization (WHO) as a rare, poorly differentiated neoplasm (i.e., an abnormal growth of cells that have an unclear identity and/or cell of origin). [3]
Atypical fibroxanthoma (AFX) of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically. [2]: 613 Atypical fibroxanthoma manifests as a hard, pink or red papule or nodule that grows over the course of several months and may bleed or ulcerate.
Pleomorphic rhabdomyosarcoma (undifferentiated rhabdomyosarcoma), also known as anaplastic rhabdomyosarcoma, is defined by the presence of pleomorphic cells with large, lobate hyperchromatic nuclei and multipolar mitotic figures. These tumors display high heterogeneity and extremely poor differentiation.
malignant fibrous histiocytoma: This tumor is now termed undifferentiated pleomorphic sarcoma (UPS) because more recently developed immunohistochemistry and cytogenetic analyses suggest that its neoplastic cells most likely arise from mesenchymal stem cells [5] or fibroblasts [6] rather than histiocytes. histiocytoma (dog)
Consequently, they have been mistakenly diagnosed as undifferentiated pleomorphic sarcoma (also termed malignant fibrous histiocytoma), rhabdomyosarcoma, [1] or other types of sarcoma [8] and treated unnecessarily with aggressive measures used for such malignancies, e.g. wide surgical resection, radiation therapy, and chemotherapy.
Sarcomatoid carcinoma is a type of rare lung tumour under the category of poorly differentiated Non-small-cell lung carcinoma (NSCLC). Based on its histological characteristics, it can be classified into giant cell carcinoma (almost completely consists of giant cells), spindle cell carcinoma (almost completely consists of spindle cells), pleomorphic carcinoma (at least 10% spindle/giant cells ...
The (US) Armed Forces Institute of Pathology has reported a figure of 10%, [43] and in a study examining over 150,000 lung cancer cases, a figure of 11.8% was given. [5] However, in the latter report the 11.8% figure was based on data that included spindle cell carcinoma , a variant which is generally considered to have a less dismal prognosis ...
Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. Fibrosarcomas mainly arise in people between the ages of 25 and 79. [1]
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