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The elimination half-life, however, was similar in both groups. The AUCs of the major circulating metabolites, 4-hydroxy duloxetine glucuronide and 5-hydroxy, 6-methoxy duloxetine sulfate, largely excreted in urine, were approximately 7- to 9-fold higher and would be expected to increase further with multiple dosing.
Do not stop using Cymbalta without first talking to your doctor. Before taking this medicine. You should not use Cymbalta if you are allergic to duloxetine. Do not take Cymbalta within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A ...
Fluvoxamine may increase duloxetine peak plasma concentrations, AUC, and half-life; substantial increases (six-fold) in duloxetine AUCs and peak plasma concentrations reported during concurrent fluvoxamine administration in poor CYP2D6 metabolizers. Monitor for signs and symptoms of serotonin syndrome; consider discontinuation if symptoms occur
Cymbalta has an average rating of 6.3 out of 10 from a total of 1891 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 30% reported a negative effect. Prozac has an average rating of 7.2 out of 10 from a total of 1227 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 20% reported a negative effect.
Cymbalta is more likely to cause weight loss early in the first 8 to 9 weeks of treatment, but result in a modest weight gain after 8 months of treatment. In general, these weight changes are minimal and may be due to temporary side effects like nausea or loss of appetite, some of the most common side effects of Cymbalta treatment.
If you miss a dose of Cymbalta, never take 2 tablets at once to make up for the missed dose because the drug has a long half-life and side effects are more likely at high plasma levels; Do not stop Cymbalta suddenly. If you want to stop taking Cymbalta, talk with your doctor who will help you to lower the dose slowly.
Cymbalta is a delayed-release product. Swallow Cymbalta capsules whole, do not crush or chew. Do not open the capsule and sprinkle on foods or liquids, because this may affect the way the contents of the capsule are absorbed. Dosages of 30 mg/day for at least one week may be desirable initially to improve tolerance to the effects of Cymbalta.
Other duloxetine brands include: Cymbalta, Irenka: Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. 17 hours. 17 hours. CSA Schedule ** View glossary of terms
Cymbalta, Drizalma Sprinkle, Irenka: Zoloft: Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. 17 hours. 66 hours. CSA Schedule ** View glossary of terms
Cymbalta, Drizalma Sprinkle, Irenka: Other venlafaxine brands include: Effexor XR: Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. 17 hours. 4 hours. CSA Schedule ** View glossary of terms