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Mesenchyme (/ ˈ m ɛ s ə n k aɪ m ˈ m iː z ən-/ [1]) is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone. [2] [3] The interactions between mesenchyme and epithelium help to form nearly every organ in the developing embryo. [4]
Mesenchyme is a type of connective tissue found in developing organs of embryos that is capable of differentiation into all types of mature connective tissue. [24] Another type of relatively undifferentiated connective tissue is the mucous connective tissue known as Wharton's jelly, found inside the umbilical cord.
Wilms' tumor (WT), also known as nephroblastoma, is an embryonic tumor originating from metanephric blastemal cells that are incapable of completing the mesenchymal-epithelial transition (MET), a crucial process during kidney differentiation involving the transition from a multipolar, spindle-shaped mesenchymal cell to a planar assembly of ...
Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary.
The sclerotome (or cutis plate) forms the vertebrae and the rib cartilage and part of the occipital bone; the myotome forms the musculature of the back, the ribs and the limbs; the syndetome forms the tendons and the dermatome forms the skin on the back.
The tissue undergoes convergent extension as the primitive streak regresses, or as the embryo gastrulates. The notochord extends from the base of the head to the tail; with it extend thick bands of paraxial mesoderm. [3] As the primitive streak continues to regress, somites form from the paraxial mesoderm by "budding off" rostrally.
Embryologic mesenchymal cells (MSC) condense into layers of vascularized primitive connective tissue. Certain mesenchymal cells group together, usually near or around blood vessels, and differentiate into osteogenic cells which deposit bone matrix constitutively. These aggregates of bony matrix are called bone spicules.
The mesenchymal tissue of dental papilla and dental sac and the ectodermal tissue of enamel undergo induction. [9] The outer cells of dental papilla are induced by preameloblasts (cells within the enamel from which a cell that takes part in forming dental enamel develops) [6] to differentiate into odontoblasts (dentin-secreting cells).