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  2. Statin - Wikipedia

    en.wikipedia.org/wiki/Statin

    The exact mechanism responsible for the possible increased risk of diabetes mellitus associated with statin use is unclear. [105] However, recent findings have indicated the inhibition of HMGCoAR as a key mechanism. [109] Statins are thought to decrease cells' uptake of glucose from the bloodstream in response to the hormone insulin. [105]

  3. Atorvastatin - Wikipedia

    en.wikipedia.org/wiki/Atorvastatin

    Statins (predominantly simvastatin) have been evaluated in clinical trials in combination with fibrates to manage dyslipidemia in people who also have type 2 diabetes, and a high cardiovascular disease risk; however, there is limited clinical benefit noted for most cardiovascular outcomes.

  4. Simvastatin - Wikipedia

    en.wikipedia.org/wiki/Simvastatin

    Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. [citation needed] Simvastatin had been shown to interact with lipid-lowering transcription factor PPAR-alpha [36] and that interaction might control the neurotrophic action of the drug.

  5. Discovery and development of statins - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Simvastatin and lovastatin are inactive lactones which must be metabolized to their active hydroxy-acid forms in order to inhibit HMGR. [7] Type 2 statins all exist in their active hydroxy-acid forms. Fluvastatin has indole ring structure, while atorvastatin and rosuvastatin have pyrrole and pyrimidine based ring structure

  6. Cholesterol absorption inhibitor - Wikipedia

    en.wikipedia.org/wiki/Cholesterol_absorption...

    Cholesterol absorption inhibitors are known to have a synergistic effect when combined a class of antihyperlipidemics called statins, to achieve an overall serum cholesterol target. For statin-resistant or statin-sensitive populations that are characterized by low one-year compliance rates, such a combination therapy is proving to be especially ...

  7. Why CVS Charges $133 More Than Costco for Generic Lipitor - AOL

    www.aol.com/news/2013-04-03-cvs-costco-generic...

    Jb Reed, Bloomberg via Getty Images By Emily Jane Fox CVS (CVS) charges $150 for a monthly prescription of the generic version of the cholesterol drug Lipitor. The same drug goes for $17 at Costco.

  8. Ezetimibe/simvastatin - Wikipedia

    en.wikipedia.org/wiki/Ezetimibe/simvastatin

    With median follow-up of 6 years, simvastatin+ezetimibe was found to reduce the primary outcome of CV mortality, major CV event, or nonfatal stroke (34.7% vs. 32.7%; P=0.016; NNT 50 per 7 years or NNT 350 per 1 year ). There was no reduction in all-cause or CV mortality with simvastatin+ezetimibe, though there was a reduction in MI and stroke. [6]

  9. 'Sushi was moving': Restaurant closes after influencer's ...

    www.aol.com/news/sushi-moving-restaurant-closes...

    A popular Washington sushi restaurant has closed two of its locations after a viral TikTok video posted by influencer Keith Lee sparked food safety concerns.

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