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Exosomes have also been shown to carry double-stranded DNA. [25] Exosomes can transfer molecules from one cell to another via membrane vesicle trafficking, thereby influencing the immune system, such as dendritic cells and B cells, and may play a functional role in mediating adaptive immune responses to pathogens and tumors.
54512 109075 Ensembl ENSG00000178896 ENSMUSG00000034259 UniProt Q9NPD3 Q921I9 RefSeq (mRNA) NM_019037 NM_175399 RefSeq (protein) NP_061910 NP_780608 Location (UCSC) Chr 8: 144.08 – 144.08 Mb Chr 15: 76.21 – 76.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex. Interactions Exosome ...
3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene. [5] [6] [7]This gene encodes a core component of the exosome complex.The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening.
The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of RNA (ribonucleic acid) molecules. Exosome complexes are found in both eukaryotic cells and archaea , while in bacteria a simpler complex called the degradosome carries out similar functions.
The stem cell secretome consists of extracellular vesicles, [1] specifically exosomes, microvesicles, membrane particles, peptides and small proteins . The paracrine activity of stem cells, i.e. the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto ...
While application of exosomes is still in its early stages, approaches are being explored to produce exosome-like nanovesicles (ELNs or artificial exosomes) to overcome these challenges. [ 7 ] [ 8 ] ELNs are a type of engineered exosomes designed to modify the structure and enhance the function of natural exosomes. [ 7 ]
Exosome may refer to: Exosome complex , an intracellular macromolecular protein complex involved in RNA degradation Exosome (vesicle) , an extracellular vesicle released from the endosomal compartment of eukaryotic cells
227715 Ensembl ENSG00000130713 ENSMUSG00000039356 UniProt Q13868 Q8VBV3 RefSeq (mRNA) NM_001282708 NM_001282709 NM_014285 NM_144886 RefSeq (protein) NP_001269637 NP_001269638 NP_055100 NP_659135 Location (UCSC) Chr 9: 130.69 – 130.71 Mb Chr 2: 31.56 – 31.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Exosome component 2, also known as EXOSC2, is a protein which in humans is ...