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The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
Ephenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injuries, and are antagonists of the NMDA receptor (K i = 66.4 nM for ephenidine).
In 2024, Shen and coworkers disclosed further studies on the biosynthesis of enediynes and reported evidence for a diiodinated trienetetrayne ((13Z)-2,13-diiodopentadeca-1,7,13-triene-3,5,9,11-tetrayne) derived from pentadeca-1,3,5,7,9,11,13-heptaene as a common biosynthetic intermediate for the three known families of enediyne natural products.
Hormone levels following a single intramuscular injection of EV/NETE (5 mg/50 mg) in healthy young men. [9] Testosterone levels were maximally suppressed by about 94%, to ~30 ng/dL, when measured at day 7. [9] EV/NETE is a combination of EV, an estrogen, and NETE, a progestogen with weak androgenic activity.
Dated to circa 1800 BCE, the Kahun Gynaecological Papyrus is the oldest known medical text in Egypt. It was found at El-Lahun by Flinders Petrie in 1889, [9] first translated by F. Ll. Griffith in 1893, and published in The Petrie Papyri: Hieratic Papyri from Kahun and Gurob.
With a single intramuscular injection of 200 mg NETE in premenopausal women, the mean maximum concentration of ethinylestradiol was 32% of that of a combined oral contraceptive containing 30 μg ethinylestradiol, the maximum equivalent oral dose of ethinylestradiol observed in the first few days of exposure was 20.3 μg/day, and the mean ...
Guanfacine, sold under the brand name Tenex (immediate-release) and Intuniv (extended-release) among others, is an oral alpha-2a agonist medication used to treat attention deficit hyperactivity disorder (ADHD) and high blood pressure.
Textbook of Aramaic Documents from Ancient Egypt, often referred to as TAD or TADAE, is a four volume corpus of Aramaic inscriptions written in Egypt during the Ancient Egyptian period, written by Bezalel Porten and Ada Yardeni.