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Lysine acetylsalicylate, also known as aspirin DL-lysine or lysine aspirin, is a more soluble form of acetylsalicylic acid (aspirin). As with aspirin itself, it is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antithrombotic and antipyretic properties. [ 1 ]
Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]
For pain or fever, effects typically begin within 30 minutes. [10] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [10] One common adverse effect is an upset stomach. [10] More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. [10]
Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]
These differential effects are due to the different roles and tissue localisations of each COX isoenzyme. [11] By inhibiting physiological COX activity, NSAIDs may cause deleterious effects on kidney function, [12] and, perhaps as a result of water and sodium retention and decreases in renal blood flow, may lead to heart problems. [13]
Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. they were only made apparent from postmarketing surveillance data collected from the wider community over longer periods of time.
Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may be avoided or decreased by means of careful and precise pharmacokinetics, the change of drug levels in the organism in function of time after administration. Adverse effects may also be caused by drug interaction. This ...
Aloxiprin (or aluminium acetylsalicylate) is a medical drug used for the treatment of pain and inflammation associated with muscular skeletal and joint disorders.It is used for its properties as an anti-inflammatory, antipyretic and analgesic drug. [1]