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Monoclonal antibody ibritumomab conjugated with tiuxetan. Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. Methods to conjugate biomolecules are applied in various field, including medicine, diagnostics, biocatalysis and materials.
A verb that does not follow all of the standard conjugation patterns of the language is said to be an irregular verb. The system of all conjugated variants of a particular verb or class of verbs is called a verb paradigm; this may be presented in the form of a conjugation table.
The bilirubin present in the plasma is largely unconjugated in this setting as they haven't been taken up and conjugated by the liver. [3] In this case, total serum bilirubin increases while the ratio of direct bilirubin to indirect bilirubin remains 96 to 4 as up to 96%-99% of bilirubin in the bile are conjugated mentioned above.
A conjugated protein is a protein that functions in interaction with other (non-polypeptide) chemical groups attached by covalent bonding or weak interactions. [ 1 ] Many proteins contain only amino acids and no other chemical groups, and they are called simple proteins.
These conjugated bile acids are often referred to as bile salts. The pKa of the unconjugated bile acids are between 5 and 6.5, [4] and the pH of the duodenum ranges between 3 and 5, so when unconjugated bile acids are in the duodenum, they are almost always protonated (HA form), which makes them relatively insoluble in water. Conjugating bile ...
Unconjugated hyperbilirubinemia arises before bilirubin reaches the liver as liver conjugation capacity is overwhelmed in haemolytic anaemias, in which red blood cells are disproportionately destroyed, leading to excessive haem metabolism thus bilirubin production. [6]
Causes of unconjugated hyperbilirubinemia are divided into three main categories, namely, excessive bilirubin synthesis, liver bilirubin uptake malfunction, and bilirubin conjugation compromise. [7] As to excessive bilirubin synthesis, both intravascular hemolysis and extravascular hemolysis can involve in the pathophysiology. [7]
Bacterial conjugation is the transfer of genetic material between bacterial cells by direct cell-to-cell contact or by a bridge-like connection between two cells. [1] This takes place through a pilus .