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  2. FoldX - Wikipedia

    en.wikipedia.org/wiki/FoldX

    For protein-protein interactions, or protein-DNA interactions FoldX calculates ∆∆G of interaction : ∆∆G ab = ∆G ab - (∆G a + ∆G b ) + ∆G kon + ∆S sc ∆G kon reflects the effect of electrostatic interactions on the k on . ∆S sc is the loss of translational and rotational entropy upon making the complex.

  3. Multiple sequence alignment - Wikipedia

    en.wikipedia.org/wiki/Multiple_sequence_alignment

    Alignments highlight mutation events such as point mutations (single amino acid or nucleotide changes), insertion mutations and deletion mutations, and alignments are used to assess sequence conservation and infer the presence and activity of protein domains, tertiary structures, secondary structures, and individual amino acids or nucleotides.

  4. Luria–Delbrück experiment - Wikipedia

    en.wikipedia.org/wiki/Luria–Delbrück_experiment

    The mechanism of resistance to the phage T1 appears to have been due to mutations in the fhuA gene - a membrane protein that acts as the T1 receptor. [20] The tonB gene product is also required for infection by T1. The FhuA protein is actively involved in the transport of ferrichrome, albomycin and rifamycin. [21]

  5. Homology modeling - Wikipedia

    en.wikipedia.org/wiki/Homology_modeling

    Homology model of the DHRS7B protein created with Swiss-model and rendered with PyMOL. Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template").

  6. De novo protein structure prediction - Wikipedia

    en.wikipedia.org/wiki/De_novo_protein_structure...

    De novo protein structure prediction methods attempt to predict tertiary structures from sequences based on general principles that govern protein folding energetics and/or statistical tendencies of conformational features that native structures acquire, without the use of explicit templates. Research into de novo structure prediction has been ...

  7. Protein design - Wikipedia

    en.wikipedia.org/wiki/Protein_design

    Protein design involves identifying novel sequences within this subset. The native state of a protein is the conformational free energy minimum for the chain. Thus, protein design is the search for sequences that have the chosen structure as a free energy minimum. In a sense, it is the reverse of protein structure prediction.

  8. Neutral network (evolution) - Wikipedia

    en.wikipedia.org/wiki/Neutral_network_(evolution)

    Neutral networks are a subset of the sequences in sequence space that have equivalent function, and so form a wide, flat plateau in a fitness landscape. Neutral evolution can therefore be visualised as a population diffusing from one set of sequence nodes, through the neutral network, to another cluster of sequence nodes.

  9. Amino acid replacement - Wikipedia

    en.wikipedia.org/wiki/Amino_acid_replacement

    Amino acid replacement is a change from one amino acid to a different amino acid in a protein due to point mutation in the corresponding DNA sequence. It is caused by nonsynonymous missense mutation which changes the codon sequence to code other amino acid instead of the original.