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Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs. [1] It acts against interleukin 31 (IL-31), [2] which is a cytokine involved in causing itchiness (pruritus). [2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks. [3]
Zoetis Inc. (/zō-EH-tis/ [4]) is an American drug company, the world's largest producer of medicine and vaccinations for pets and livestock. [5] [4] [6] The company was a subsidiary of Pfizer, [7] the world's largest drug maker, but with Pfizer's spinoff of its 83% interest in the firm it is now a completely independent company.
Checkpoint inhibitor therapy is a form of cancer immunotherapy.The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.
TKIs operate by four different mechanisms: they can compete with adenosine triphosphate (ATP), the phosphorylating entity, the substrate or both or can act in an allosteric fashion, namely bind to a site outside the active site, affecting its activity by a conformational change. [14]
Examples of toxic agents are toxic metals, toxic chemicals, microbe neurotoxins, radiation particles and even specific neurotransmitters when the system is out of balance. Also some types of drugs, e.g alcohol , [ 1 ] and some venom , e.g. from the puff adder ( Bitis arietans ) or brown recluse spider ( Loxosceles reclusa ) are toxic to cells.
The Fiddler in the Subway: The True Story of What Happened When a World-Class Violinist Played for Handouts -- and Other Virtuoso Performances by America's Foremost Feature Writer. New York: Simon & Schuster. ISBN 978-1-4391-8160-7. OCLC 891943904. [59] Weingarten, Gene; Shansby, Eric (illustrations) (2014). Me & Dog. New York: Simon & Schuster ...
If there is a start with joint ownership (where each party has veto power over the use of the asset) and move to a situation in which there is a single owner, the investment incentives of the new owner are improved while the investment incentives of the other parties remain the same; however, in the basic incomplete contracting framework, the ...
For example, doctors and patients are linked to each other in such a way that private information is passed within their boundaries constantly. These linkages can be strong or weak depending on how information was shared or whether a co-owner wanted to know or was prepared to learn a new piece of information.