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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb , an essential activator of mTORC1.
Unlike the TCR, the TSC is only ever operated fully on or fully off. An attempt to operate a TSC in ‘’phase control’’ would result in the generation of very large amplitude resonant currents, leading to overheating of the capacitor bank and thyristor valve, and harmonic distortion in the AC system to which the SVC is connected.
When serving in a joint environment where the army is the dominant service, the TSC could provide core elements of a single, joint logistics command and control capability. [ 1 ] Theater sustainment commands
A Linux boot log showing the usage of TSC as system clocksource. The Time Stamp Counter (TSC) is a 64-bit register present on all x86 processors since the Pentium. It counts the number of CPU cycles since its reset. The instruction RDTSC returns the TSC in EDX:EAX. In x86-64 mode, RDTSC also clears the upper 32 bits of RAX and RDX. Its opcode ...
The Minié ball is a cylindro-conoidal bullet with grease-filled cannelures on its exterior and a cone-shaped hollow in its base.Minié designed the bullet with a small iron plug, and lead skirting that would expand under the pressure of gunpowder deflagration causing the bullet to obturate, and grip the rifling grooves.